"The Core of ‘Mind and Cosmos'" Review

My review of Dr. Nagel's book "Mind and Cosmos" applauded his opening thesis but declared the whole a failure. After asserting that consciousness could never be accounted for by a purely-physical theory he limited his further analysis to issues posed by traditional philosophic categories. I wanted him instead to deduce what the appearance of consciousness meant for evolution itself. That is, I wanted him to extrapolate from the known, consciousness, to the unknown, evolution, no matter where pre-evolutionary philosophizing stood on the matter. 

In a summary published as "Opinionator" in the New York Times Dr. Nagel makes up for his lapse by simply omitting the offending analysis. For an authoritative statement of the mission of this site I can't do better than direct you to https://opinionator.blogs.nytimes.com/2013/08/18/the-core-of-mind-and-cosmos/

What I, as publisher of this site, am missing is a picture of how students in the humanities are responding to his call-to-arms. These are the people I am trying to reach with this site. Would someone please tell them.




Denis Noble Challenges neo-Darwinism

Summary of "Evolution beyond neo-Darwinism: a new conceptual framework," The Journal of Experimental Biology, (2015) 218.

“We are moving to a much more nuanced multi-mechanism theory of evolution.” In this article, with “Lamarck” and “systems biology” among its keywords, Denis Noble issues a no-holds-barred challenge to apologists for the modern synthesis. 

“The language of new-Darwinism and 20th century biology reflect highly reductionist philosophical and scientific viewpoints, the concepts of which are not required by the scientific discoveries themselves.” These concepts form “a biased interpretative veneer that can hide those discoveries in a web of interpretation. I refer to a web of interpretation as it is the whole conceptual scheme of new-Darwinism that creates the difficulty. Each concept and metaphor reinforces the overall mindset until it is almost impossible to stand outside it and appreciate how beguiling it is.” 

The main body of the article consists of detailed analyses of terms associated with the reductionist viewpoint he wants to supplant: “gene,” “selfish,” “code,” “program,” “blueprint,” “book of life,” “replicator” and “vehicle.” A few quotes: “There is no biological experiment that could distinguish between the selfish gene theory and its opposites, such as ‘imprisoned’ or ‘cooperative’ genes” “The postulate of a ‘genetic program’ led to the idea that an organism is fully defined by its genome, whereas in fact the inheritance of cell structures is equally important.” “As the Nobel-prize winner Barbara McClintock said, the genome is an ‘organ of the cell,’ not the other way round.” Later he says, “It is therefore easy to represent the three-dimensional structure of the cell as containing as much information as the genome…. Genes are best viewed therefore as causes in a passive sense. They do nothing until activated. Active causation lies with proteins, membranes, organelles, etc., and the dynamical functional networks they form in interaction with the environment.” 

Some of his closing remarks: 

“We can then ask what would be an alternative approach better fitted to what we now know experimentally and to a new more integrated system view.” Phrases he uses in conjunction with this new view include “dynamic functional networks,” “self-templating,” “transgenerational inheritance,” “non-random variation,” as well of course as “epigenetic.” Let’s hope the phrases get shortened as time goes by.

“The alternative form of representation depends on two fundamental concepts. The first one is the distinction between active and passive causes... The second concept is that there is no privileged level of causation.” “Active causation resides in the networks, which include many components for which there are no DNA templates. It is the physics and chemistry of those dynamic networks that determine what happens.” 

“An important linguistic feature of the alternative, relativistic, concepts proposed here is that most or all the anthropomorphic features of the new-Darwinist language can be eliminated without contravening a single biological experimental fact. There may be other forms of representation that can achieve the same result. It doesn’t really matter which you use. The aim is simply to distance ourselves from the biased conceptual scheme that neo-Darwinism has brought to biology, made more problematic by the fact that it has been presented as literal truth…. By so conclusively excluding anything that might be interpreted as Lamarckism, it assumed what couldn’t be proved.

On this site we carry a review of Noble’s book “The Music of Life.”


Evolution, neo-Darwinism and the paradigm of science

Evolution, neo-Darwinism and the paradigm of science
By Edward Goldsmith

Published in The Ecologist Vol. 20 No. 2, March–April 1990. Read the article at www.edwardgoldsmith.org/890/evolution-ne...paradigm-of-science/

Neo-Darwinism does not provide a satisfactory explanation for evolution and, however resilient it may prove to criticism, it must eventually give way to a more realistic theory. This can only occur if we abandon the reductionistic and mechanistic ‘paradigm of science’, which neo-Darwinism so faithfully reflects.

Extract: "Yet, although the deficiencies of neo-Darwinism have become increasingly apparent in recent years, and criticism has mounted on almost every front, it remains the official scientific explanation for evolution.

"There appear to be two reasons for its continued dominance. The first is that it is the only theory of evolution that is, or appears to be fully consistent with the ‘paradigm of science’. The second is that the critics have not yet provided a coherent alternative to neo-Darwinism but have rather sought to modify it in different ways so that it might incorporate their various criticisms."

The secret power of the single cell

By Brian J. Ford

This article is included in our "Critique of Darwinism" section because accounting for the whole cell faces the Modern Synthesis with perhaps its greatest and most easily marshaled challenge.

Originally published in the New Scientist, 24 April 2010, included here by permission of the author.

Original subtitle: Is a neuron really a tiny computer? How do lowly amoebae build complex shells? Single cells may tell us a lot about the roots of intelligence,

LATE at night on a sultry evening, I watch intently as the predator senses its prey, gathers itself, and strikes. It could be a polecat, or even a mantis – but in fact it’s a microbe. The microscopic world of the single, living cell mirrors our own in so many ways: cells are essentially autonomous, sentient and ingenious. In the lives of single cells we can perceive the roots of our own intelligence.

Molecular biology and genetics have driven the biosciences, but have not given us the miraculous new insights we were led to expect. From professional biologists to schoolchildren, people are concentrating on the minutiae of what goes on in the deepest recesses of the cell. For me, however, this misses out on life in the round: it is only when we look at the living cell as a whole organism that wonderful realities emerge that will alter our perception not only of how single cells enact their intricate lives but what we humans truly are.

The problem is that whole-cell biology is not popular. Microscopy is hell-bent on increased resolution and ever higher magnification, as though we could learn more about animal behaviour by putting a bacon sandwich under lenses of increasing power. We know much about what goes on within parts of a cell, but so much less about how whole cells conduct their complex lives.

Currently, cell biology deals largely with the components within cells, and systems biology with how the components interact. There is nothing to counterbalance this reductionism with a focus on how whole cells behave. Molecular biology and genetics are the wrong sciences to tackle the task.

Let’s take a look at some of the evidence for ingenuity and intelligence in cells that is missing from the curriculum. Take the red algae Rhodophyta, where many species carry out remarkable repairs to damaged cells. Cut a filament of Antithamnion cells so the cell is cut across and the cytoplasm escapes into the surrounding aquatic medium. All that remains are two fragments of empty, disrupted cell wall lying adjacent to, but separate from, each other. Within 24 hours, however, the adjacent cells have made good the damage, the empty cell space has been restored to full activity, and the cell walls meticulously realigned and seamlessly repaired.

The only place where this can happen is in the lab. In nature, the broken ends of the severed cell would nearly always end up remote from each other, so selection in favour of an automatic repair mechanism through Darwinian evolution would be impossible. Yet something amazing is happening here: because the damage to the Antithamnion filament is unforeseeable, the organism faces a situation for which it has not been able to adapt, and is therefore unable to call upon inbuilt responses. It has to use some sort of problem-solving ingenuity instead.

We regard amoeba as simple and crude. Yet many types of amoeba construct glassy shells by picking up sand grains from the mud in which they live. The typical Difflugia shell, for example, is shaped like a vase, and has a remarkable symmetry.

Compare this with the better known behaviour of a caddis fly larva. This maggot hunts around the bottom of the pond for suitable scraps of detritus with which to construct a home. Water-logged wood is cemented together with pondweed until the larva has formed a protective covering for its nakedness. You might think this comparable to the home built by the testate amoeba, yet the amoeba lacks the jaws, eyes, muscles, limbs, cement glands and brain the caddis fly larva relies on for its skills. We just don’t know how this single-celled organism builds its shell, and molecular biology can never tell us why. While the home of the caddis fly larva is crude and roughly assembled, that of the testate amoeba is meticulously crafted – and it’s all made by a single cell.

The products of the caddis fly larva and the amoeba, and the powers of red algae are about more than ingenuity: they pose important questions about cell intelligence. After all, whole living cells are primarily autonomous, and carry out their daily tasks with little external mediation. They are not subservient nanobots, they create and regulate activity, respond to current conditions and, crucially, take decisions to deal with unforeseen difficulties.

Just how far this conceptual revolution about cells could take us becomes clearer with more complex animals, such as humans. Here, conventional wisdom is that everything is ultimately controlled by the brain. But cells in the liver, for example, reproduce at just the right rate to replace cells lost through attrition; follicular cells create new hair; bone marrow cells produce new circulating blood cells at a rate of millions per minute. And so on and on. In fact, around 90 per cent of this kind of cell activity is invisible to the brain, and the cells are indifferent to its actions. The brain is an irrelevance to most somatic cells.

So where does that leave the neuron, the most highly evolved cell we know? It ought to be in an interesting and privileged place. After all, neurons are so specialised that they have virtually abandoned division and reproduction. Yet we model this cell as little more than an organic transistor, an on/off switch. But if a red alga can “work out” how to solve problems, or an amoeba construct a stone home with all the “ingenuity” of a master builder, how can the human neuron be so lowly?

Unravelling brain structure and function has come to mean understanding the interrelationship between neurons, rather than understanding the neurons themselves. My hunch is that the brain’s power will turn out to derive from data processing within the neuron rather than activity between neurons. And networks of neurons enhance the effect of those neurons “thinking” between themselves. I think the neuron’s action potentials are rather like a language neurons use to transmit processed data from one to the next.

Back in 2004, we set out to record these potentials, from neurons cultured in the lab. They emit electrical signals of around 40 hertz, which sound like a buzzing, irritating noise played back as audio files. I used some specialist software to distinguish the signal within the noise – and to produce sound from within each peak that is closer to the frequency of a human voice and therefore more revealing to the ear.

Listening to the results reprocessed at around 300 Hz, the audio files have the hypnotic quality of sea birds calling. There is a sense that each spike is modulated subtly within itself, and it sounds as if there are discrete signals in which one neuron in some sense “addresses” another. Could we be eavesdropping on the language of the brain?

For me, the brain is not a supercomputer in which the neurons are transistors; rather it is as if each individual neuron is itself a computer, and the brain a vast community of microscopic computers. But even this model is probably too simplistic since the neuron processes data flexibly and on disparate levels, and is therefore far superior to any digital system. If I am right, the human brain may be a trillion times more capable than we imagine, and “artificial intelligence” a grandiose misnomer.

I think it is time to acknowledge fully that living cells make us what we are, and to abandon reductionist thinking in favour of the study of whole cells. Reductionism has us peering ever closer at the fibres in the paper of a musical score, and analysing the printer’s ink. I want us to experience the symphony.

Waddington's Unfinished Critique of Neo-Darwinian Genetics

Waddington’s Unfinished Critique
of Neo-Darwinian Genetics: Then and Now

Adam S. Wilkins
Department of Zoology
University of Cambridge
Cambridge, UK
This email address is being protected from spambots. You need JavaScript enabled to view it.


Abstract: C.H.Waddington is today remembered chiefly as a Drosophila developmental geneticist who developed the concepts of canalization and the epigenetic landscape. In his lifetime, however, he was widely perceived primarily as a critic of Neo-Darwinian evolutionary theory. His criticisms of Neo- Darwinian evolutionary theory were focused on what he saw as unrealistic, atomistic models of both gene selection and trait evolution. In particular, he felt that the Neo-Darwinians badly neglected the phenomenon of extensive gene interactions and that the randomness of mutational effects, posited in the theory, was a false postulate. This last criticism dealt with the phenomenon known today as developmental constraints. Although population genetics itself has evolved considerably from its form at mid-20th century, much of Waddington's critique, it is argued here, retains cogency. Yet, he did not attempt to develop a full-fledged alternative theory himself. Perhaps most surprisingly, in retrospect, is that he did not try to marry his work on gene interactions in development with his evolutionary interests, to create a theory of genetic networks and their evolution. Whether evolutionary genetics today will incorporate network thinking as a central element or whether there will be a general retreat to the more atomistic approach offered by genomics remains an open question.